Počet záznamů: 1  

Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients

  1. 1.
    0474103 - UIVT-O 2018 RIV US eng J - Článek v odborném periodiku
    Stádníková, A. - Ďuďáková, L. - Skalická, P. - Valenta, Zdeněk - Filipec, M. - Jirsová, K.
    Active Transforming Growth Factor-beta2 in the Aqueous Humor of Posterior Polymorphous Corneal Dystrophy Patients.
    PLoS ONE. Roč. 12, č. 4 (2017), č. článku e0175509. E-ISSN 1932-6203
    Grant ostatní:GA ČR(CZ) GA17-12355S; GA MŠk(CZ) 7F14156
    Institucionální podpora: RVO:67985807
    Klíčová slova: transforming growth factor-beta2 * posterior polymorphous corneal dystrophy * corneal endothelial cells * general linear mixed-effect modelling * restricted maximum likelihood estimation
    Kód oboru RIV: BB - Aplikovaná statistika, operační výzkum
    Obor OECD: Statistics and probability
    Impakt faktor: 2.766, rok: 2017

    Posterior polymorphous corneal dystrophy (PPCD) is characterized by abnormal proliferation of corneal endothelial cells. It was shown that TGF-beta2 present in aqueous humor (AH) could help maintaining the corneal endothelium in a G1-phase-arrest state. We wanted to determine whether the levels of this protein are changed in AH of PPCD patients. The level of active TGF-beta2 in the AH of all PPCD patients (mean +/- SD, 386.98 +/- 114.88 pg/ml) in comparison to the control group (260.95 +/- 112.43 pg/ml) was significantly higher (P = 0.0001). Compared to the control group, a significantly higher level of active TGF- beta2 was found in the PPCD1 (P = 0.0005) and PPCDx (P = 0.0022) groups. Levels of active TGF- beta2 were not significantly affected by gender, age, secondary glaucoma or by the progression of dystrophy when one or repeated PK were performed.
    Trvalý link: http://hdl.handle.net/11104/0271223