Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer

0473778 - BTÚ 2018 RIV US eng J - Článek v odborném periodiku
Rohlenová, Kateřina - Sachaphibulkij, K. - Stursa, J. - Bezawork-Geleta, A. - Blecha, Jan - Endaya, B. - Werner, L. - Černý, Jiří - Zobalová, Renata - Goodwin, J. - Špaček, Tomáš - Pesdar, E.A. - Yan, B. - Nguyen, M.N. - Vondrusová, Magdaléna - Sobol, Margaryta - Ježek, Petr - Hozák, Pavel - Truksa, Jaroslav - Rohlena, Jakub - Dong, L.F. - Neužil, Jiří
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2(high) Breast Cancer.
Antioxidants & Redox Signaling. Roč. 26, č. 2 (2017), s. 84-103. ISSN 1523-0864. E-ISSN 1557-7716
Grant CEP: GA ČR(CZ) GA16-12719S; GA ČR(CZ) GA16-22823S; GA ČR GA13-28830S; GA ČR(CZ) GA16-12816S; GA TA ČR(CZ) TE01020118; GA MPO FR-TI3/588; GA MŠMT(CZ) LQ1604; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036 ; RVO:67985823 ; RVO:68378050
Klíčová slova: mitochondrially targeted tamoxifen * HER2 * respirasome
Obor OECD: Biochemistry and molecular biology; Oncology (FGU-C); Biochemistry and molecular biology (UMG-J)
Impakt faktor: 6.530, rok: 2017

Aims: Expression of the HER2 oncogene in breast cancer is associated with resistance to treatment, and Her2 may regulate bioenergetics. Therefore, we investigated whether disruption of the electron transport chain (ETC) is a viable strategy to eliminate Her2(high) disease.
Trvalý link: http://hdl.handle.net/11104/0270919