Carbonic anhydrase inhibitors and method of their production

0473218 - ÚMG 2017 RIV eng P - Patentový dokument
Brynda, Jiří - Cígler, P. - Gruner, B. - Řezáčová, Pavlína - Mader, Pavel - Šícha, V. - Bakardjiev, M. - Holub, J. - Džubák, P. - Hajdúch, M.
Carbonic anhydrase inhibitors and method of their production.
2016. Vlastník: Ústav organické chemie a viochemie AV ČR, v. v. i., Ústav molekulární genetiky AV ČR, v. v. i., Ústav anorganické chemie AV ČR, v. v. i., Univerzita Palackého v Olomouci. Datum udělení patentu: 22.03.2016. Číslo patentu: US9290529
Institucionální podpora: RVO:68378050
Klíčová slova: cancer enzyme * inhibition * carboranes
Kód oboru RIV: EB - Genetika a molekulární biologie
https://usapatents.us/us-9290529.html

Derivatives of boron cluster compounds of general formula I and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. Methods of synthesis and the use of the novel derivatives. These inhibitors of human carbonic anhydrase IX can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
Trvalý link: http://hdl.handle.net/11104/0270376