Počet záznamů: 1
Carbonic anhydrase inhibitors and method of their production
- 1.0473217 - ÚMG 2017 RIV eng P - Patentový dokument
Brynda, Jiří - Cígler, P. - Gruner, B. - Řezáčová, Pavlína - Mader, Pavel - Šícha, V. - Bakardjiev, M. - Holub, J. - Džubák, P. - Hajdúch, M.
Carbonic anhydrase inhibitors and method of their production.
2016. Vlastník: Ústav organické chemie a viochemie AV ČR, v. v. i., Ústav molekulární genetiky AV ČR, v. v. i., Ústav anorganické chemie AV ČR, v. v. i., Univerzita Palackého v Olomouci. Datum udělení patentu: 16.03.2016. Číslo patentu: EP2771015
Institucionální podpora: RVO:68378050
Klíčová slova: cancer enzyme * inhibition * carboranes
Kód oboru RIV: EB - Genetika a molekulární biologie
https://worldwide.espacenet.com/publicationDetails/biblio?CC=EP&NR=2771015A1&KC=A1&date=&FT=D&locale=en_EP#
The invention describes new derivatives of boron cluster compounds of general formula (I) and their pharmaceutically acceptable salts and solvates, and their specific inhibition effect on the enzyme carbonic anhydrase IX, a protein overexpressed in cancer tissues. The invention also includes methods of synthesis and the use of the novel derivatives. The inhibitiors of human carbonic anhydrase IX of this invention can be used as active compounds of pharmaceuticals for diagnostics and/or therapy of cancer diseases.
Trvalý link: http://hdl.handle.net/11104/0270374
Počet záznamů: 1