Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells

0473134 - BTÚ 2017 RIV GB eng J - Článek v odborném periodiku
Váňová, K. - Boukalová, Štěpána - Gbelcová, H. - Muchová, L. - Neužil, Jiří - Gürlich, R. - Ruml, T. - Vítek, L.
Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells.
Bmc Cancer. Roč. 16, May 12 (2016), č. článku 309. E-ISSN 1471-2407
Grant CEP: GA MZd NT14078; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:86652036
Klíčová slova: Heme * Heme oxygenase * Pancreatic cancer * Statins
Kód oboru RIV: FD - Onkologie a hematologie
Impakt faktor: 3.288, rok: 2016

Background: Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways. In healthy tissues, statins activate the heme oxygenase pathway, nevertheless the role of heme oxygenase in pancreatic cancer is still controversial. The aim of this study was to evaluate, whether anti-proliferative effects of statins in pancreatic cancer cells are mediated via the heme oxygenase pathway.
Trvalý link: http://hdl.handle.net/11104/0270305