Role of actin cytoskeleton at multiple levels of T cell activation

0473098 - ÚMG 2017 RIV US eng J - Článek v odborném periodiku
Huranová, Martina - Štěpánek, Ondřej
Role of actin cytoskeleton at multiple levels of T cell activation.
AIMS Molecular Science. Roč. 3, č. 4 (2016), s. 585-596. ISSN 2372-0301
Grant CEP: GA ČR GJ16-09208Y
Institucionální podpora: RVO:68378050
Klíčová slova: T cell * actin * cytoskeleton * TCR * signal transduction * antigen recognition * antigen affinity threshold * immunological synapse
Kód oboru RIV: EB - Genetika a molekulární biologie

Actin cytoskeleton is an essential cellular structure that is involved in many physiological aspects, including T cell antigenic responses. In has been proposed that actin modulates biophysical parameters of the antigen recognition, forms a barrier inhibiting spontaneous signaling in resting T cells, facilitates TCR signal transduction, stabilizes contacts between T cells and antigen presenting cells, and contributes to the establishment of the antigen affinity threshold. In this review, we discuss the role of actin cytoskeleton at these particular levels of T cell activation.
Trvalý link: http://hdl.handle.net/11104/0270261