RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS

0472832 - FGÚ 2017 RIV ME eng C - Konferenční příspěvek (zahraniční konf.)
Pavelka, Stanislav
RADIOMETRIC DETERMINATION OF THYROTOXIC EFFECTS OF SOME XENOBIOTICS.
RAD 2015: THE THIRD INTERNATIONAL CONFERENCE ON RADIATION AND APPLICATIONS IN VARIOUS FIELDS OF RESEARCH. Niš: RAD ASSOC, 2015 - (Ristić, G.), s. 463-466. ISBN 978-86-80300-01-6.
[International Conference on Radiation and Applications in Various Fields of Research (RAD) /3./. Budva (ME), 08.06.2015-12.06.2015]
Grant ostatní: AV ČR(CZ) SAV-15-03
Program: Bilaterální spolupráce
Institucionální podpora: RVO:67985823
Klíčová slova: bromide * perchlorate * thyroid hormones * radiometric determination * xenobiotics
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa

Recently, we have shown in the isolated rat thyroid glands marked effects of excessive exogenous bromide and perchlorate ions on the activity of thyroid peroxidase (TPO), the key enzyme in thyroid hormones (TH) metabolism. Here, we studied in more details effects of an enhanced bromide and/or perchlorate intake on various aspects of iodine metabolism and, consequently, on TH metabolism in the rat. With the use of several radioanalytical methods, including adapted radiometric determination of TPO enzyme activity, we confirmed and quantified the presumed thyrotoxic effects of xenobiotics bromide and perchlorate ions.
Trvalý link: http://hdl.handle.net/11104/0270050