Analysis of high-frequency activity in electroencephalogram of animal epilepsy model

0472016 - FGÚ 2017 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
Havel, T. - Kudláček, J. - Jiruška, Přemysl - Ježdík, P. - Čmejla, R.
Analysis of high-frequency activity in electroencephalogram of animal epilepsy model.
International Workshop on Computational Intelligence for Multimedia Understanding. Praha: IEEE, 2015. ISBN 978-1-4673-8457-5.
[INTERNATIONAL WORKSHOP ON COMPUTATIONAL INTELLIGENCE FOR MULTIMEDIA UNDERSTANDING. Praha (CZ), 29.10.2015-30.10.2015]
Grant CEP: GA MZd(CZ) NT14489; GA ČR(CZ) GA14-02634S
Institucionální podpora: RVO:67985823
Klíčová slova: epilepsy * animal model * electroencephalogram (EEG) * high-frequency oscillations (HFO)
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

High frequency oscillations (HFO) are believed to be a new specific biomarker of epileptogenic tissue. According to the reported findings, we hypothesized that HFOs occur more specific to the epileptogenic tissue. To test this hypothesis, we analyzed intracranial electroencephalograms (iEEG) of three subjects of animal epilepsy model. Overall 180 minutes of iEEG records were processed by the automatic high frequency activity detector and further analyzed. The dominant frequency of each segment was determined and categorized as ripples (80-200 Hz) or fast ripples (200-1000 Hz). Even though overall number of HFO detections predominate in the hemisphere where epileptic focus is located, in comparison of each brain structure separately our hypothesis cannot be fully confirmed.
Trvalý link: http://hdl.handle.net/11104/0269369