Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles

0471967 - BFÚ 2017 RIV DE eng J - Článek v odborném periodiku
Medrikova, Z. - Novohradský, Vojtěch - Zajac, Juraj - Vrána, Oldřich - Kašpárková, Jana - Bakandritsos, A. - Petr, M. - Zbořil, R. - Brabec, Viktor
Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose-Coated Magnetic Nanoparticles.
Chemistry - A European Journal. Roč. 22, č. 28 (2016), s. 9750-9759. ISSN 0947-6539. E-ISSN 1521-3765
Grant CEP: GA MŠMT(CZ) LH14317; GA ČR(CZ) GA14-21053S
Institucionální podpora: RVO:68081707
Klíčová slova: iron-oxide nanoparticles * maghemite nanoparticles * nanocrystal clusters * anticancer drugs
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 5.317, rok: 2016

The fabrication of nanoparticles using different formulations, and which can be used for the delivery of chemotherapeutics, has recently attracted considerable attention. We describe herein an innovative approach that may ultimately allow for the selective delivery of anticancer drugs to tumor cells by using an external magnet. A conventional antitumor drug, cisplatin, has been incorporated into new carboxymethylcellulose-stabilized magnetite nanoparticles conjugated with the fluorescent marker Alexa Fluor 488 or folic acid as targeting agent. The magnetic nanocarriers possess exceptionally high biocompatibility and colloidal stability. These cisplatin-loaded nanoparticles overcome the resistance mechanisms typical of free cisplatin. Moreover, experiments aimed at the localization of the nanoparticles driven by an external magnet in a medium that mimics physiological conditions confirmed that this localization can inhibit tumor cell growth site-specifically.
Trvalý link: http://hdl.handle.net/11104/0269327