Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction

0471939 - BFÚ 2017 RIV NL eng J - Článek v odborném periodiku
Koudelka, Adolf - Ambrožová, Gabriela - Klinke, A. - Fidlerová, Táňa - Martíšková, Hana - Kuchta, R. - Rudolph, T.K. - Kadlec, J. - Kuchtová, Z. - Woodcock, S.R. - Freeman, B.A. - Kubala, Lukáš - Pekarová, Michaela
Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction.
Cardiovascular Drugs and Therapy. Roč. 30, č. 6 (2016), s. 579-586. ISSN 0920-3206. E-ISSN 1573-7241
Grant CEP: GA ČR GP13-40824P; GA MŠMT(CZ) LD15069
Institucionální podpora: RVO:68081707
Klíčová slova: fatty acids * arterial-hypertension * oxide synthase * murine model
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 2.820, rok: 2016

Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aimed to explore the effect of nitro-oleic acid (OA-NO2), an exemplary nitro-fatty acid (NO2-FA), in human pulmonary artery endothelial cells (HPAEC) under the influence of hypoxia or ADMA.
Trvalý link: http://hdl.handle.net/11104/0269301