14-3-3 Proteins: A Family of Versatile Molecular Regulators

0471750 - FGÚ 2017 CZ eng J - Článek v odborném periodiku
Obšilová, Veronika - Šilhan, J. - Bouřa, Evžen - Teisinger, Jan - Obšil, Tomáš
14-3-3 Proteins: A Family of Versatile Molecular Regulators.
Physiological Research. Roč. 57, Suppl.3 (2008), S11-S21. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠMT(CZ) LC554; GA AV ČR(CZ) IAA501110801; GA AV ČR(CZ) KJB500110601
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: 14-3-3 protein * forkhead transcription factor FOXO4 * tyrosine hydroxylase * conformation
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 1.653, rok: 2008

The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
Trvalý link: http://hdl.handle.net/11104/0269080