Helquat derivatives, preparation thereof, and use thereof as medicaments

0471683 - ÚOCHB 2017 RIV eng P - Patentový dokument
Teplý, Filip - Hájek, Miroslav
Helquat derivatives, preparation thereof, and use thereof as medicaments.
2016. Vlastník: Ústav organické chemie a biochemie AV ČR, v. v. i. Datum udělení patentu: 02.06.2016. Číslo patentu: AU2014207125
Institucionální podpora: RVO:61388963
Klíčová slova: helquat derivatives * cellular proliferation diseases * medicaments
Kód oboru RIV: CC - Organická chemie
https://worldwide.espacenet.com/publicationDetails/biblio?CC=AU&NR=2014207125B2&KC=B2&FT=D&ND=8&date=20160602&DB=&locale=en_EP#

The invention provides helquat derivatives of general formula I, wherein substituents R1 and R2 are independently selected from a group comprising H and C1 to C3 alkyl; up to three of S1,2, S1',2', S3,4 and S3', 4' are present, each of S1,2, S1',2', S3,4 and S3',4' independently represents a linker consisting of a bivalent hydrocarbon chain having 3-6 carbon atoms; one or two atoms selected from the carbon atoms with the descriptor 2, 4, 2', and 4' are substituted with a substituent R3 of general formula II or general formula III wherein R4 is substituted or unsubstituted aryl; T1 and T2 independently represent a bivalent hydrocarbon chain having 2-5 carbon atoms; and anions (X1)- and (X2)- independently represent anions of pharmaceutically acceptable salts. The helquat derivatives are useful as medicaments in the treatment of diseases related to increased cellular proliferation, such as oncologic diseases.
Trvalý link: http://hdl.handle.net/11104/0269506