POLYPEPTIDE ANTAGONISTS OF HUMAN IL-23 RECEPTOR FOR TREATMENT OF AUTOIMMUNE DISEASES

0470240 - BTÚ 2017 RIV eng P - Patentový dokument
Malý, Petr - Šebo, Peter - Kuchař, Milan - Vaňková, Lucie - Petroková, Hana - Osička, Radim
POLYPEPTIDE ANTAGONISTS OF HUMAN IL-23 RECEPTOR FOR TREATMENT OF AUTOIMMUNE DISEASES.
2017. Vlastník: Biotechnologický ústav AV ČR, v. v. i. Datum udělení patentu: 04.01.2017. Číslo patentu: EP2922560
Institucionální podpora: RVO:86652036 ; RVO:61388971
Klíčová slova: psoriasis * IL - 23 * binding protein
Kód oboru RIV: EB - Genetika a molekulární biologie; EE - Mikrobiologie, virologie (MBU-M)
https://worldwide.espacenet.com/publicationDetails/biblio?II=0&ND=3&adjacent=true&locale=cz_CZ&FT=D&date=20150930&CC=EP&NR=2922560A1&KC=A1#

The present invention provides a novel class of polypeptides (REX binders), derived from an albumin-binding domain of the streptococcal protein G that inhibit binding of human IL-23 cytokine to its cognate IL-23 receptor. Blocking of interaction between p19/IL-23 subunit with the receptor leads to the suppresion of IL-23-dependent pro-inflammatory signaling pathway, resulting in an inhibitory effect on IL-23-stimulated Th-17 cell expansion. The invention further provides a DNA sequence encoding for such polypeptides and host cells containing such sequence. The polypeptides of the invention are useful as therapeutics and diagnostics.˙
Trvalý link: http://hdl.handle.net/11104/0267957