Determination of stability constants of [Gly6]-antamanide complexes with small cations by affinity capillary electrophoresis

0469328 - ÚOCHB 2017 CZ eng C - Konferenční příspěvek (zahraniční konf.)
Pangavhane, Sachin - Makrlík, E. - Ruzza, P. - Kašička, Václav
Determination of stability constants of [Gly6]-antamanide complexes with small cations by affinity capillary electrophoresis.
Advances in Chromatography and Electrophoresis & Chiranal 2016. Olomouc: Palacký University, 2016 - (Maier, V.), s. 131-132. ISBN 978-80-244-4961-6.
[Advances in Chromatography and Electrophoresis & Chiranal 2016. Olomouc (CZ), 06.06.2016-09.06.2016]
Grant CEP: GA ČR(CZ) GA15-01948S
Institucionální podpora: RVO:61388963
Klíčová slova: affinity capillary electrophoresis * [Gly6]-antamanide * stability constant
Kód oboru RIV: CB - Analytická chemie, separace

Affinity capillary electrophoresis (ACE) was employed for the determination of apparent stability constants Kst of complexes of cyclic peptide [Gly6]-antamanide ([Gly6]-AA) with alkali and alkali-earth metal ions: Li+, Na+, K+, Rb+, Cs+, NH4+, and Ca2+. Kst was determined from the dependence of effective mobility of [Gly6]-AA on the concentration of these ions in the background electrolyte using the non-linear regression analysis. Kst were found to be in the range 13.3 – 26.3.
Trvalý link: http://hdl.handle.net/11104/0267200