MUTANT POLYPEPTIDES SUAA AND POLYPEPTIDE DERIVATIVES SUITABLE FOR DELIVERY OF IMMUNOGENIC MOLECULES IN CELL

0469308 - MBÚ 2017 RIV eng P - Patentový dokument
Šebo, Peter - Osičková, Adriana - Mašín, Jiří - Fayolle, C. - Krůšek, Jan - Basler, Marek - Leclerc, C. - Osička, Radim
MUTANT POLYPEPTIDES SUAA AND POLYPEPTIDE DERIVATIVES SUITABLE FOR DELIVERY OF IMMUNOGENIC MOLECULES IN CELL.
2016. Vlastník: Institut Pasteur (FR)- Fyziologický ústav AV ČR,v. v. i.- Mikrobiologický ústav AV ČR, v. v. i. Datum udělení patentu: 27.05.2016. Číslo patentu: RU2585216
Grant CEP: GA ČR GA310/08/0447; GA MŠMT 2B06161
Institucionální podpora: RVO:61388971 ; RVO:67985823
Klíčová slova: Bordetella pertusis * adenylate cyclase protein
Kód oboru RIV: EE - Mikrobiologie, virologie; ED - Fyziologie (FGU-C)
https://worldwide.espacenet.com/publicationDetails/biblio?CC=RU&NR=2585216C2&KC=C2&FT=D&ND=4&date=20160527&DB=&loc ale=en_EP#

The invention relates to mutant CyaA/E570Q+K860 polypeptides suitable for use as proteinaceous vectors for delivering one or more molecules of interest into a cell, in particular into a cell expressing the CD11b receptor. The invention further relates to polypeptide derivatives suitable for eliciting an immune response in a host. The invention is more particularly directed to polypeptides derived from an adenylate cyclase protein (CyaA) either under the form of a toxin or of a toxoid, which are mutant polypeptides. Said mutant polypeptides are capable of retaining the binding activity of native CyaA to a target cell and preferably of also retaining the translocating activity of native CyaA through its N-terminal domain into target cells and furthermore have a pore-forming activity which is reduced or suppressed as compared to that of the native CyaA toxin.
Trvalý link: http://hdl.handle.net/11104/0267340