Method for analysis of psychopharmaceuticals in real industrial wastewater and groundwater with suspended organic particulate matter using solid phase extraction disks extraction and ultra-high performance liquid chromatography/time-of-flight mass spectrometry

0467463 - MBÚ 2017 RIV NL eng J - Článek v odborném periodiku
Křesinová, Zdena - Linhartová, Lucie - Petrů, Klára - Krejčová, L. - Šrédlová, Kamila - Lhotský, O. - Kameník, Zdeněk - Cajthaml, Tomáš
Method for analysis of psychopharmaceuticals in real industrial wastewater and groundwater with suspended organic particulate matter using solid phase extraction disks extraction and ultra-high performance liquid chromatography/time-of-flight mass spectrometry.
Journal of Chromatography A. Roč. 1440, APR 1 (2016), s. 15-22. ISSN 0021-9673. E-ISSN 1873-3778
Grant CEP: GA TA ČR TE01020218
Institucionální podpora: RVO:61388971
Klíčová slova: Pharmaceuticals * SPE disks * Whole-water
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 3.981, rok: 2016

A rapid and reliable analytical method was developed for the quantitative determination of psychopharmaceuticals, their precursors and by-products in real contaminated samples from a pharmaceutical company in Olomouc (Czech Republic), based on SPE disk extraction and detection by ultra performance liquid chromatography, combined with time-of-flight mass spectrometry. The target compounds were quantified in the real whole-water samples (water including suspended particles), both in the presence of suspended particulate matter (SPM) and high concentrations of other organic pollutants. A total of nine compounds were analyzed which consisted of three commonly used antidepressants (tricyclic antidepressants and antipsychotics), one antitussive agent and five by-products or precursors. At first, the SPE disk method was developed for the extraction of water samples (dissolved analytes, recovery 84-104%) and pressurised liquid extraction technique was verified for solid matrices (sludge samples, recovery 81-95%). In order to evaluate the SPE disk technique for whole water samples containing SPM, non contaminated groundwater samples were also loaded with different amounts (100 and 300 mg L-1) of real contaminated sludge originating from the same locality. The recoveries from the whole-water samples obtained by SPE disk method ranged between 67 and 119% after the addition of the most contaminated sludge. The final method was applied to several real groundwater (whole-water) samples from the industrial area and high concentrations (up to 10(3) mu g L-1) of the target compounds were detected. The results of this study document and indicate the feasibility of the SPE disk method for analysis of groundwater.
Trvalý link: http://hdl.handle.net/11104/0266227