EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation

0467243 - ÚPT 2017 RIV US eng J - Článek v odborném periodiku
Eskilsson, E. - Rosland, G.V. - Talasila, K.M. - Knappskog, S. - Keunen, O. - Sottoriva, A. - Foerster, S. - Solecki, G. - Taxt, T. - Jiřík, Radovan - Fritah, S. - Harter, P.N. - Valk, K. - Al Hossain, J. - Joseph, J.V. - Jahedi, R. - Saed, H.S. - Piccirillo, S.G. - Spiteri, I. - Leiss, L. - Euskirchen, P. - Graziani, G. - Daubon, T. - Lund-Johansen, M. - Enger, P.O. - Winkler, F. - Ritter, C. - Niclou, Simone P. - Watts, C. - Bjerkvig, R. - Miletic, H.
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.
Neuro-Oncology. Roč. 18, č. 12 (2016), s. 1644-1655. ISSN 1522-8517. E-ISSN 1523-5866
Grant CEP: GA ČR GAP102/12/2380; GA MŠMT(CZ) LO1212
Institucionální podpora: RVO:68081731
Klíčová slova: angiogenesis * EGFR * EGFRvIII * glioblastoma * invasion
Kód oboru RIV: BH - Optika, masery a lasery
Impakt faktor: 7.786, rok: 2016

Background. Amplification of the epidermal growth factor receptor (EGFR) and its mutant EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most frequent and most aggressive primary brain tumor.
Trvalý link: http://hdl.handle.net/11104/0265373