Distributed capillary adiabatic tissue homogeneity model in parametric multi-channel blind AIF estimation using DCE-MRI

0466902 - ÚPT 2017 RIV US eng J - Článek v odborném periodiku
Kratochvíla, Jiří - Jiřík, Radovan - Bartoš, M. - Standara, M. - Starčuk jr., Zenon - Taxt, T.
Distributed capillary adiabatic tissue homogeneity model in parametric multi-channel blind AIF estimation using DCE-MRI.
Magnetic Resonance in Medicine. Roč. 75, č. 3 (2016), s. 1355-1365. ISSN 0740-3194. E-ISSN 1522-2594
Grant CEP: GA ČR GAP102/12/2380; GA MŠMT(CZ) LO1212; GA MŠMT ED0017/01/01
Institucionální podpora: RVO:68081731
Klíčová slova: dynamic contrast-enhanced magnetic resonance imaging * multi-channel blind deconvolution * arterial input function * impulse residue function * renal cell carcinoma
Kód oboru RIV: BM - Fyzika pevných látek a magnetismus
Impakt faktor: 3.924, rok: 2016

PurposeOne of the main challenges in quantitative dynamic contrast-enhanced (DCE) MRI is estimation of the arterial input function (AIF). Usually, the signal from a single artery (ignoring contrast dispersion, partial volume effects and flow artifacts) or a population average of such signals (also ignoring variability between patients) is used.
MethodsMulti-channel blind deconvolution is an alternative approach avoiding most of these problems. The AIF is estimated directly from the measured tracer concentration curves in several tissues. This contribution extends the published methods of multi-channel blind deconvolution by applying a more realistic model of the impulse residue function, the distributed capillary adiabatic tissue homogeneity model (DCATH). In addition, an alternative AIF model is used and several AIF-scaling methods are tested.
ResultsThe proposed method is evaluated on synthetic data with respect to the number of tissue regions and to the signal-to-noise ratio. Evaluation on clinical data (renal cell carcinoma patients before and after the beginning of the treatment) gave consistent results. An initial evaluation on clinical data indicates more reliable and less noise sensitive perfusion parameter estimates.
ConclusionBlind multi-channel deconvolution using the DCATH model might be a method of choice for AIF estimation in a clinical setup.
Trvalý link: http://hdl.handle.net/11104/0265083