It takes two T to shape immunity: emerging role for T-type calcium channels in immune cells

0466576 - ÚOCHB 2017 SK eng J - Článek v odborném periodiku
Lacinová, L. - Weiss, Norbert
It takes two T to shape immunity: emerging role for T-type calcium channels in immune cells.
General Physiology and Biophysics. Roč. 35, č. 4 (2016), s. 393-396. ISSN 0231-5882. E-ISSN 1338-4325
Grant CEP: GA ČR GA15-13556S; GA MŠMT 7AMB15FR015
Institucionální podpora: RVO:61388963
Klíčová slova: calcium channel * T-type channel * Ca(v)3.1 * immune cells
Kód oboru RIV: CE - Biochemie
Impakt faktor: 1.170, rok: 2016

T-type channels are defined as low-voltage-activated calcium channels, characterized by a low activation threshold that makes these channels perfectly suited to operate near the resting membrane potential of most electrically excitable cells. For instance, T-type channels play fundamentally important roles in shaping intrinsic neuronal excitability (Perez-Reyes 2003), and contribute to the pacemaker function in the heart (Cribbs 2010). Although T-type channels may be inactivated at rest and require brief periods of hyperpolarization to recover from inactivation, a significant fraction of channels may remain open supporting a "window current" that allows the passive influx of calcium inside the cell (Crunelli et al. 2005). The window calcium current may serve important physiological functions. For instance, passive calcium entry through T-type channels modulates the resting membrane potential of nerve cells (Dreyfus et al. 2010). A role for the window current in the differentiation of myoblasts has also been documented (Bijlenga et al. 2000). In addition, steady-state entry of calcium through T-type channels may also play important roles in non-excitable cells per se. Indeed, the expression of T-type channels is not restricted to excitable cells and has been documented in a number of non-neuronal tissues including fibroblasts (Peres et al. 1988), lung (Zhou and Wu 2006), liver (Li et al. 2009), pancreas (Braun et al. 2008), kidney (Hayashi et al. 2007), and also in female (Ohkubo et al. 2005) and male reproductive tissues (Darszon et al. 2006), where T-type channels may play complex yet fundamentally important (patho)physiological functions. The window current supported by T-type channels may also be of direct relevance to an interesting recent study by Wang and colleagues (Wang et al. 2016) published in Immunity, on the role of T-type channels in the immune system.
Trvalý link: http://hdl.handle.net/11104/0264848