Direct comparison of ASL and DCE-MRI in a mouse model of cancer

0466416 - ÚPT 2017 RIV DE eng C - Konferenční příspěvek (zahraniční konf.)
Krátká, Lucie - Jiřík, Radovan - Dražanová, Eva - Souček, Karel - Starčuk jr., Zenon
Direct comparison of ASL and DCE-MRI in a mouse model of cancer.
Magma. Vol. 29 S1. Berlin: Springer, 2016, S289-S290. E-ISSN 1352-8661.
[ESMRMB 2016 Congress. Vienna (AT), 29.09.2016-01.10.2016]
Grant CEP: GA ČR(CZ) GA16-13830S; GA MŠMT(CZ) LO1212
Institucionální podpora: RVO:68081731 ; RVO:68081707
Klíčová slova: ASL * DCE-MRI
Kód oboru RIV: BM - Fyzika pevných látek a magnetismus; BM - Fyzika pevných látek a magnetismus (BFU-R)
http://link.springer.com/journal/10334/29/1/suppl/page/1

In recent years, several studies comparing ASL vs. DCE-MRI appeared due to an expansion of ASL from brain applications also to other organs (e.g. pulmonary parenchyma(1), tumour(2)). These studies indirectly compared blood flow (Fb) estimated with ASL to the perfusion parameters estimated by DCE-MRI which are only related to Fb but not equivalent. Our DCE-MRI method3 is based on the ATH pharmacokinetic model(4) providing estimates of Fb. This provides a direct comparison of the same quantity estimated using ASL and DCE-MRI. Compared to previous approaches aiming at replacement of one method by another, this study aims to prepare their combination and to provide more reliable perfusion-parameter estimate.
Trvalý link: http://hdl.handle.net/11104/0264782