Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E

0465781 - MBÚ 2017 RIV eng P - Patentový dokument
Petříček, Miroslav - Petříčková, Kateřina - Pospíšil, Stanislav - Kuzma, Marek - Chroňáková, Alica - Krištůfek, Václav - Stříž, I.
Manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E.
2016. Vlastník: Biologické centrum AV ČR, v. v. i.- Mikrobiologický ústav AV ČR, v. v. i.- Institut klinické a experimentální medicíny. Datum udělení patentu: 20.09.2016. Číslo patentu: US9447062
Grant CEP: GA MŠMT(CZ) LO1509
Institucionální podpora: RVO:61388971 ; RVO:60077344
Klíčová slova: colabomycin E * production of colabomycin E * Streptomyceus aureus SOK1/5-04
Kód oboru RIV: EE - Mikrobiologie, virologie
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=9,447,062.PN.&OS=PN/9,447,062&RS=PN/9,447,062

A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strain Streptomyces aureus SOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from Streptomyces griseoflavus. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1β release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.
Trvalý link: http://hdl.handle.net/11104/0264295