Počet záznamů: 1
Green Biocatalysis
- 1.0465386 - MBÚ 2017 RIV US eng M - Část monografie knihy
Martínková, Ludmila
Nitrile-Converting Enzymes and their Synthetic Applications.
Green Biocatalysis. Hoboken, New Jersey: John Wiley & Sons, 2016 - (Patel, R.), s. 331-350. ISBN 9781118822296
Grant CEP: GA ČR(CZ) GAP504/11/0394
Institucionální podpora: RVO:61388971
Klíčová slova: Nitrilase * Nitrile hydratase * Metagenome
Kód oboru RIV: EE - Mikrobiologie, virologie
The enzymatic hydrolysis of nitriles proceeds via two different pathways: a two step pathway catalyzed by nitrile hydratase and amidase, and a single‐step pathway catalyzed by nitrilase. Nitrile hydratase and nitrilase belong to different protein superfamilies, and their phylogenetic distribution is also different (nitrilases in plants, fungi, and bacteria but nitrile hydratases almost exclusively in bacteria). Nitrilases (EC 3.5.5.-.) belong to the nitrilase superfamily, that is, nonpeptide C-N hydrolases with a Glu-Lys-Cys catalytic triad, and nitrile hydratases (4.2.1.84) are metalloenzymes containing a ferric or a cobalt (III) ion in their catalytic site. Due to their ability to transform an immense number of man‐made nitriles, the nitrile-converting enzymes have found widespread use in synthetic organic chemistry. The advantages of enzymatic processes reside in their mild conditions, high yields, and high purities of the products and in their regio- or enantioselectivities.
Trvalý link: http://hdl.handle.net/11104/0264311
Počet záznamů: 1