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Synthesis of S-(28a-homobetulin-28a-yl) thiophosphate, thiophosphonate, and thiophosphinate
- 1.0464036 - ÚEB 2017 RIV GB eng J - Článek v odborném periodiku
Sidoryk, K. - Cmoch, P. - Rárová, L. - Oklešťková, Jana - Pakulski, Z. - Strnad, Miroslav
Synthesis of S-(28a-homobetulin-28a-yl) thiophosphate, thiophosphonate, and thiophosphinate.
Phosphorus, Sulfur and Silicon and the Related Elements. Roč. 191, č. 9 (2016), s. 1240-1244. ISSN 1042-6507. E-ISSN 1563-5325
Grant CEP: GA MŠMT(CZ) LO1204; GA ČR GA14-19590S
Institucionální podpora: RVO:61389030
Klíčová slova: terpenoids * homothiophosphabetulin * Homothiobetulin
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 0.809, rok: 2016
A concise synthesis of thiophosphate, phenylthiophosphonate, and diphenylthiophosphinate esters bearing a 28a-homolupane residue is reported. The new triterpenes were obtained from the readily available 3-O-acetylichopanol by a nucleophilic substitution of the corresponding mesylate with thiocyanate ion followed by a Michaelis-Arbuzov reaction. These results open the way to new lupane-type derivatives having a thiophosphorus moiety at the lupane core as potential anticancer compounds. Additionally, the cytotoxic activities of the new homolupane compounds were evaluated in vitro.
Trvalý link: http://hdl.handle.net/11104/0263101
Název souboru Staženo Velikost Komentář Verze Přístup 2016_Sidoryk_PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS_1240.pdf 2 415.6 KB Jiná povolen
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