Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition

0463779 - BFÚ 2017 RIV NL eng J - Článek v odborném periodiku
Ambrožová, Gabriela - Fidlerová, Táňa - Vereščáková, Hana - Koudelka, Adolf - Rudolph, T.K. - Woodcock, S.R. - Freeman, B.A. - Kubala, Lukáš - Pekarová, Michaela
Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition.
Biochimica et Biophysica Acta-General Subjects. Roč. 1860, č. 11 (2016), s. 2428-2437. ISSN 0304-4165. E-ISSN 1872-8006
Grant CEP: GA ČR(CZ) GP13-40824P
Institucionální podpora: RVO:68081707
Klíčová slova: Nitro-oleic acid * Endothelial cells * Macrophages
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.702, rok: 2016

Background: Inflammatory-mediated pathological processes in the endothelium arise as a consequence of the dysregulation of vascular homeostasis. Of particular importance are mediators produced by stimulated monocytes/macrophages inducing activation of endothelial cells (ECs). This is manifested by excessive soluble pro-inflammatory mediator production and cell surface adhesion molecule expression. Nitro-fatty acids are endogenous products of metabolic and inflammatory reactions that display immuno-regulatory potential and may represent a novel therapeutic strategy to treat inflammatory diseases. The purpose of our study was to characterize the effects of nitro-oleic acid (OA-NO2) on inflammatory responses and the endothelial-mesenchymal transition (EndMT) in ECs that is a consequence of the altered healing phase of the immune response.
Trvalý link: http://hdl.handle.net/11104/0262863