The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis

0463355 - MBÚ 2017 RIV US eng J - Článek v odborném periodiku
Heissigerová, J. - Seidler Stangová, P. - Klímová, A. - Svozilová, P. - Hrnčíř, Tomáš - Štěpánková, Renata - Kverka, Miloslav - Tlaskalová-Hogenová, Helena - Forrester, J.V.
The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis.
Journal of Immunology Research. Roč. 2016, č. 1 (2016), s. 1-11. ISSN 2314-8861. E-ISSN 2314-7156
Grant CEP: GA ČR(CZ) GA15-09518S; GA MZd NT14017
Institucionální podpora: RVO:61388971
Klíčová slova: GUT MICROBIOTA * T-CELL * INFLAMMATION
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.276, rok: 2016

The microbiota is a crucial modulator of the immune system. Here, we evaluated how its absence or reduction modifies the inflammatory response in the murine model of experimental autoimmune uveoretinitis (EAU). We induced EAU in germ-free (GF) or conventionally housed (CV) mice and in CV mice treated with a combination of broad-spectrum antibiotics either from the day of EAU induction or from one week prior to induction of disease. The severity of the inflammation was assessed by fundus biomicroscopy or by histology, including immunohistology. The immunophenotyping of T cells in local and distant lymph nodes was performed by flow cytometry.
Trvalý link: http://hdl.handle.net/11104/0263322