Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions

0461854 - BC 2017 RIV GB eng J - Článek v odborném periodiku
Chmelař, J. - Kotál, Jan - Karim, S. - Kopáček, Petr - Francischetti, I.M.B. - Pedra, J. H. F. - Kotsyfakis, Michalis
Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions.
Trends in Parasitology. Roč. 32, č. 3 (2016), s. 242-254. ISSN 1471-4922. E-ISSN 1471-5007
Grant CEP: GA ČR GAP502/12/2409; GA ČR GA13-11043S
GRANT EU: European Commission(XE) 268177
Institucionální podpora: RVO:60077344
Klíčová slova: next-generation sequencing * sialomes * systems biology * tick-borne pathogens
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 6.333, rok: 2016

Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.
Trvalý link: http://hdl.handle.net/11104/0261421