Počet záznamů: 1
N-15-labelled pyrazines of triterpenic acids
- 1.0460853 - ÚEB 2017 RIV HU eng J - Článek v odborném periodiku
Vlk, M. - Mičolová, P. - Urban, M. - Kvasnica, Miroslav - Šaman, David - Šarek, J.
N-15-labelled pyrazines of triterpenic acids.
Journal of Radioanalytical and Nuclear Chemistry. Roč. 308, č. 2 (2016), s. 733-739. ISSN 0236-5731. E-ISSN 1588-2780
Grant CEP: GA ČR GJ15-08202Y; GA MŠMT(CZ) LO1304; GA MŠMT(CZ) LO1204
Grant ostatní: GA MŠk(CZ) LK21310; GA TA ČR(CZ) TA03010027; CTU(CZ) SGS15/094/OHK4/1T/14
Institucionální podpora: RVO:61389030 ; RVO:61388963
Klíčová slova: N-15 * Triterpenic acid * Isotopic labelling
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 1.282, rok: 2016
Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC50 in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their N-15 labelled analogs. In this work, we present the synthesis and characterization of the target N-15 labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.
Trvalý link: http://hdl.handle.net/11104/0260829
Název souboru Staženo Velikost Komentář Verze Přístup 2016_Vlk_JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY_733.pdf 2 518.2 KB Jiná povolen
Počet záznamů: 1