The impact of silica encapsulated cobalt zinc ferrite nanoparticles on DNA, lipids and proteins of rat bone marrow mesenchymal stem cells.

0459627 - ÚEM 2017 RIV GB eng J - Článek v odborném periodiku
Novotná, Božena - Turnovcová, Karolína - Veverka, Pavel - Rössner ml., Pavel - Bagryantseva, Yana - Herynek, Vít - Zvatora, P. - Vosmanská, M. - Klementová, M. - Syková, Eva - Jendelová, Pavla
The impact of silica encapsulated cobalt zinc ferrite nanoparticles on DNA, lipids and proteins of rat bone marrow mesenchymal stem cells.
Nanotoxicology. Roč. 10, č. 6 (2016), s. 662-670. ISSN 1743-5390. E-ISSN 1743-5404
Grant CEP: GA ČR(CZ) GAP304/12/1370; GA MŠMT(CZ) LO1309; GA MŠMT(CZ) LO1508
Institucionální podpora: RVO:68378041 ; RVO:68378271
Klíčová slova: comet assay * cytotoxicity * genotoxicity * lipid peroxidation
Obor OECD: Cell biology
Impakt faktor: 6.428, rok: 2016
Způsob publikování: Omezený přístup
https://www.tandfonline.com/doi/full/10.3109/17435390.2015.1107144

Cobalt zinc ferrite nanoparticles (Co0.5Zn0.5Fe2O4+γ [CZF-NPs]) encapsulated by amorphous silica we prepared and tested in order to find a safe contrast agent and magnetic label for tracking transplanted cells within an organism using magnetic resonance imaging (MRI). No harmful effects were detected in cells exposed to the low dose of CZF-NPs. Nevertheless, the labeled cells still exhibited an adequate relaxation rate for MRI in repeated experiments and ICP-MS confirmed sufficient magnetic label concentrations inside the cells.
Trvalý link: http://hdl.handle.net/11104/0259808