Beta-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia

0458525 - FGÚ 2017 RIV SK eng J - Článek v odborném periodiku
Hahnová, K. - Kašparová, D. - Žurmanová, J. - Neckář, Jan - Kolář, František - Novotný, J.
Beta-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia.
General Physiology and Biophysics. Roč. 35, č. 2 (2016), s. 165-173. ISSN 0231-5882. E-ISSN 1338-4325
Grant CEP: GA ČR(CZ) GAP303/12/1162
Institucionální podpora: RVO:67985823
Klíčová slova: rat myocardium * chronic hypoxia * beta-adrenergic receptors * adenylyl cyclase
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 1.170, rok: 2016

Chronic hypoxia may produce a cardioprotective phenotype characterized by increased resistance to ischemia-reperfusion injury. Nevertheless, the molecular basis of cardioprotective effects of hypoxia is still not quite clear. The present study investigated the consequences of a 3-week adaptation to cardioprotective (CNH, continuous normobaric hypoxia) and nonprotective (INH, intermittent normobaric hypoxia; 23 h/day hypoxia followed by 1 h/day reoxygenation) regimen of hypoxia on beta-adrenergic signaling in the rat myocardium. Both regimens of hypoxia lowered body weight and led to marked right ventricular (RV) hypertrophy, which was accompanied by 25% loss of beta1-adrenergic receptors (beta1-ARs) in the RV. No significant changes were found in beta-ARs in left ventricular (LV) preparations from animals adapted to hypoxia. Although adenylyl cyclase (AC) activity stimulated through the G proteins was decreased in the RV and increased in the LV after exposure to hypoxia, there were no significant changes in the expression of the dominant myocardial AC 5/6 isoforms and the stimulatory G proteins. These data suggest that chronic normobaric hypoxia may strongly affect myocardial beta-adrenergic signaling but adaptation to cardioprotective and nonprotective regimens of hypoxia does not cause notably diverse changes.
Trvalý link: http://hdl.handle.net/11104/0258786