Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications

0458295 - ÚMCH 2017 RIV GB eng J - Článek v odborném periodiku
Jäger, Eliezer - Höcherl, Anita - Janoušková, Olga - Jäger, Alessandro - Hrubý, Martin - Konefal, Rafal - Netopilík, Miloš - Pánek, Jiří - Šlouf, Miroslav - Ulbrich, Karel - Štěpánek, Petr
Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications.
Nanoscale. Roč. 8, č. 13 (2016), s. 6958-6963. ISSN 2040-3364. E-ISSN 2040-3372
Grant CEP: GA MŠMT(CZ) 7F14009; GA MPO(CZ) FR-TI4/625; GA MŠMT(CZ) LH14292; GA MŠMT(CZ) LO1507; GA TA ČR(CZ) TE01020118
Institucionální podpora: RVO:61389013
Klíčová slova: reactive oxygen species (ROS) * responsive nanoparticles * fluorescence life-time imaging (FLIM)
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 7.367, rok: 2016

A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.
Trvalý link: http://hdl.handle.net/11104/0258578