Age-related changes in the lateral lipid distribution in a human lens described by mass spectrometry imaging

0456001 - MBÚ 2016 RIV GB eng J - Článek v odborném periodiku
Pól, Jaroslav - Faltýsková, Helena - Krásný, Lukáš - Volný, Michael - Vláčil, O. - Hajdúch, M. - Lemr, Karel - Havlíček, Vladimír
Age-related changes in the lateral lipid distribution in a human lens described by mass spectrometry imaging.
European Journal of Mass Spectrometry. Roč. 21, č. 3 (2015), s. 297-303. ISSN 1469-0667
Grant CEP: GA MŠMT(CZ) LD13038; GA MŠMT LO1509
Grant ostatní: OPPC(XE) CZ.2.16/3.1.00/24023
Institucionální podpora: RVO:61388971
Klíčová slova: lens * eye * imaging
Kód oboru RIV: CB - Analytická chemie, separace
Impakt faktor: 1.011, rok: 2015

The lateral lipid distribution in eye lenses of three human donors were studied by matrix-assisted laser desorption ionization imaging mass spectrometry using a high mass resolution. By using exact mass measurements this study shows the relationship between the aging process and the number of lipids detected as well as between aging and the abundance of products derived from sphingomyelins by hydrolysis. Variable lipid composition was also observed in the nuclear, barrier, or cortex regions of the lens samples. This is the first study that suggests the distribution of lysolipids as a potential biomarker panel for the aging of human lens tissue.
Trvalý link: http://hdl.handle.net/11104/0256582