Are Subthalamicus Nucleus, Internal, Globus Pallidus and Thalamus Involved in Thinking?

0455912 - ÚPT 2016 GB eng A - Abstrakt
Minks, E. - Jurák, Pavel - Chládek, Jan - Hummelová, Z.
Are Subthalamicus Nucleus, Internal, Globus Pallidus and Thalamus Involved in Thinking?
Journal of Neurology Neurosurgery and Psychiatry. Roč. 86, e4 (2015), s. 46. ISSN 0022-3050. E-ISSN 1468-330X.
[Annual Meeting of the Association-of-British-Neurologists (ABN). 10.09.2015, London]
Institucionální podpora: RVO:68081731
Klíčová slova: Subthalamicus Nucleus * Globus Pallidus * Involving Thinking
Kód oboru RIV: BH - Optika, masery a lasery

The aim was to compare evoked potentials (EP) from the P300 paradigm against mismatch negativity (MMN) paradigm, both recorded in the subthalamic nucleus (STN), internal globus pallidus (GPi) and thalamus (Th) and thus electrophysiologically isolate conscious cognition component in these structures. We included 8 patients in Deep brain stimulation program and recorded EP (patients with Parkinson's disease, Generalized dystonia, Essential tremor, Epilepsy). The two four-contacts intracerebral electrodes were implanted into the left and right STN, GPi or Th bilaterally. We computed local potentials on the left and right electrode and we studied the latency of cognitive response (from 200 to 400 ms). In the comparison of infrequent stimuli related P300 and MMN a significant difference was found in 14 from 16 electrodes. Comparing frequent answers we found significant difference in 13 from 16 electrodes. The difference between evoked potentials of MMN and P300 protocols in 200–400 ms latency suggests that STN, GPi and Th are involved in conscious cognitive processes at the time of stimuli application.
Trvalý link: http://hdl.handle.net/11104/0256510