Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis

0455742 - ÚMG 2016 RIV US eng J - Článek v odborném periodiku
Procházka, Jan - Procházková, Michaela - Du, W. - Špoutil, František - Turečková, Jolana - Hoch, R. - Schimogori, T. - Sedláček, Radislav - Rubenstein, J.L. - Wittmann, T. - Klein, O. D.
Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis.
Developmental Cell. Roč. 35, č. 6 (2015), s. 713-724. ISSN 1534-5807. E-ISSN 1878-1551
Grant CEP: GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:68378050
Klíčová slova: Lateral-line * mammalian tooth * zebrafish
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 9.338, rok: 2015

The proper positioning of organs during development is essential, yet little is known about the regulation of this process in mammals. Using murine tooth development as a model, we have found that cell migration plays a central role in positioning of the organ primordium. By combining lineage tracing, genetic cell ablation, and confocal live imaging, we identified a migratory population of Fgf8-expressing epithelial cells in the embryonic mandible. These Fgf8-expressing progenitors furnish the epithelial cells required for tooth development, and the progenitor population migrates toward a Shh-expressing region in the mandible, where the tooth placode will initiate. Inhibition of Fgf and Shh signaling disrupted the oriented migration of cells, leading to a failure of tooth development. These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ.
Trvalý link: http://hdl.handle.net/11104/0256361