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Biotransformation of fluoroquinolone antibiotics by ligninolytic fungi - Metabolites, enzymes and residual antibacterial activity
- 1.0455597 - MBÚ 2016 RIV GB eng J - Článek v odborném periodiku
Čvančarová, Monika - Moeder, M. - Filipová, Alena - Cajthaml, Tomáš
Biotransformation of fluoroquinolone antibiotics by ligninolytic fungi - Metabolites, enzymes and residual antibacterial activity.
Chemosphere. Roč. 136, OCT 2015 (2015), s. 311-320. ISSN 0045-6535. E-ISSN 1879-1298
Grant CEP: GA TA ČR TE01020218; GA ČR GA13-28283S
Institucionální podpora: RVO:61388971
Klíčová slova: Fluoroquinolone antibiotics * White rot fungi * Residual antibacterial activity
Kód oboru RIV: EE - Mikrobiologie, virologie
Impakt faktor: 3.698, rok: 2015
A group of white rot fungi (Irpex lacteus, Panus tigrinus, Dichomitus squalens, Trametes versicolor and Pleurotus ostreatus) was investigated for the biodegradation of norfloxacin (NOR), ofloxacin (OF) and ciprofloxacin (CIP). The selected fluoroquinolones were readily degraded almost completely by I. lacteus and T. versicolor within 10 and 14 d of incubation in liquid medium, respectively. The biodegradation products were identified by liquid chromatography-mass spectrometry. The analyses indicated that the fungi use similar mechanisms to degrade structurally related antibiotics. The piperazine ring of the molecules is preferably attacked via either substitution or/and decomposition. In addition to the degradation efficiency, attention was devoted to the residual antibiotic activities estimated using Gram-positive and Gram-negative bacteria. Only I. lacteus was able to remove the antibiotic activity during the course of the degradation of NOR and OF. The product-effect correlations evaluated by Principal Component Analysis (PCA) enabled elucidation of the participation of the individual metabolites in the residual antibacterial activity.
Trvalý link: http://hdl.handle.net/11104/0256215
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