Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide

0455314 - ÚOCHB 2016 RIV IT eng J - Článek v odborném periodiku
Harmatha, Juraj - Vokáč, Karel - Buděšínský, Miloš - Zídek, Zdeněk - Kmoníčková, Eva
Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide.
Fitoterapia. Roč. 107, Dec (2015), s. 90-99. ISSN 0367-326X. E-ISSN 1873-6971
Grant CEP: GA ČR GA305/07/0061
Institucionální podpora: RVO:61388963 ; RVO:68378041
Klíčová slova: sesquiterpene lactones * guaianolides * trilobolide derivatives * nitric oxide * cytokines * immunoactivity
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.408, rok: 2015

Search for compounds with preserved immunobiological properties and decreased cytotoxicity led us to transform some structural features of trilobolide, particularly those related to their side chain functionality. For this reason, it was prepared over 20 various deacylated, acyl modified, or relactonized derivatives of trilobolide. Their immunobiological effects were screened in vitro using the rat peritoneal cells primed with lipopolysaccharide. Secretion of interferon-gamma (IFN-gamma), interleukins (IL) IL-1beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) were determined by ELISA, and nitric oxide (NO) production by Griess reagent.
Trvalý link: http://hdl.handle.net/11104/0255933