Epigenetics and a new look on metabolic syndrome

0454386 - FGÚ 2016 RIV CZ eng J - Článek v odborném periodiku
Kuneš, Jaroslav - Vaněčková, Ivana - Mikulášková, Barbora - Behuliak, Michal - Maletínská, L. - Zicha, Josef
Epigenetics and a new look on metabolic syndrome.
Physiological Research. Roč. 64, č. 5 (2015), s. 611-620. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MZd(CZ) NV15-25396A; GA ČR(CZ) GA15-08679S
Institucionální podpora: RVO:67985823
Klíčová slova: metabolic syndrome * epigenetics * transgenerational inheritance * gene-environmental interactions * obesity * hypertension
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 1.643, rok: 2015

The ability of environmental factors to promote phenotype changes by epigenetic DNA modifications (i.e. DNA methylation, histone modifications) was demonstrated to play an important role in the development and predisposition to particular symptoms of metabolic syndrome. There is no doubt that the early life, such as the fetal and perinatal periods, is critical for metabolic syndrome development and therefore critical for prevention of this disease. Moreover, these changes are visible not only in individuals exposed to environmental factors but also in the subsequent progeny for multiple generations and this phenomenon is called transgenerational inheritance
Trvalý link: http://hdl.handle.net/11104/0255075