Cardioprotective adaptation of rats to intermittent hypobaric hypoxia is accompanied by the increased association of hexokinase with mitochondria

0454176 - FGÚ 2016 RIV US eng J - Článek v odborném periodiku
Wasková-Arnoštová, P. - Elsnicová, B. - Kašparová, D. - Horníková, D. - Kolář, František - Novotný, J. - Žurmanová, J.
Cardioprotective adaptation of rats to intermittent hypobaric hypoxia is accompanied by the increased association of hexokinase with mitochondria.
Journal of Applied Physiology. Roč. 119, č. 12 (2015), s. 1487-1493. ISSN 8750-7587. E-ISSN 1522-1601
Institucionální podpora: RVO:67985823
Klíčová slova: hexokinase * mitochondrial colocalization * cardioprotection * chronic hypoxia * rat heart
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 3.004, rok: 2015

We found significantly elevated expression of HK isoforms (HK1 and HK2) in left ventricular myocardium of rats adapted to severe intermittent hypoxia. Hypoxia also increased the total HK activity and the association of HK isoforms with mitochondria in both ventricles. These findings suggest that HK may contribute to the cardioprotective phenotype induced by adaptation to intermittent hypoxia
Trvalý link: http://hdl.handle.net/11104/0254873