Information transfer through a signaling module with feedback: A perturbative approach

0454137 - FGÚ 2016 RIV IE eng J - Článek v odborném periodiku
Aquino, G. - Zápotocký, Martin
Information transfer through a signaling module with feedback: A perturbative approach.
Biosystems. Roč. 136, Oct (2015), s. 66-72. ISSN 0303-2647. E-ISSN 1872-8324
Grant CEP: GA ČR(CZ) GBP304/12/G069
Institucionální podpora: RVO:67985823
Klíčová slova: signal transduction * communication channel * poisson process * information theory * feedback loop * Non-Markovian process
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 1.495, rok: 2015

Signal transduction in biological cells is effected by signaling pathways that typically include multiple feedback loops. Here we analyze information transfer through a prototypical signaling module with biochemical feedback. Using a novel perturbative approach, we compute the rate with which information about the input is gained from observation of the output. We obtain an explicit analytical result valid to first order in feedback strength and to second order in the strength of input
Trvalý link: http://hdl.handle.net/11104/0254835