Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa

0452542 - ARÚ 2016 RIV GB eng J - Článek v odborném periodiku
Podgorná, Eliška - Diallo, I. - Vangenot, Ch. - Sanchez-Mazas, A. - Sabbagh, A. - Černý, Viktor - Poloni, E. S.
Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa.
BMC Evolutionary Biology. Roč. 15, č. 263 (2015). ISSN 1471-2148. E-ISSN 1471-2148
Grant CEP: GA ČR GA13-37998S
Institucionální podpora: RVO:67985912
Klíčová slova: NAT2 * acetylation polymorphism * African Sahel * pastoral nomads * subsistence mode * ecoregion * natural selection
Kód oboru RIV: AC - Archeologie, antropologie, etnologie
Impakt faktor: 3.406, rok: 2015
http://www.biomedcentral.com/1471-2148/15/263

The main shift in subsistence strategies is associated with dietary changes in Neolithic and subsequent population differentiations as far as the food-production lifestyle concerns. However, we show in this study that the genetic structure of human populations living in the African Sahel corresponds more strongly with ecoregions than to subsistence strategies. Our results thus suggest a possible independent influence of both the dietary habits associated with subsistence modes and the chemical environment associated with climatic zones and biomes on the evolution of NAT2 diversity in sub-Saharan African populations.
Trvalý link: http://hdl.handle.net/11104/0253564