Comparison of P300 and MMN protocols in subthalamicus nucleus, internal globus pallidus and thalamus. Are these subcortical structures involved in thinking?

0452200 - ÚPT 2016 CZ eng A - Abstrakt
Minks, E. - Jurák, Pavel - Chládek, Jan - Hummelová, Z. - Halámek, Josef - Minksová, A. - Bareš, M.
Comparison of P300 and MMN protocols in subthalamicus nucleus, internal globus pallidus and thalamus. Are these subcortical structures involved in thinking?
15th European Congress on Clinical Neuro­physiology. Book of Abstracts. Brno: Česká a slovenská společnost pro klinickou neurofyziologii, 2015. s. 273.
[European Congress on Clinical Neuro­physiology /15./. 30.09.2015-04.10.2015, Brno]
Institucionální podpora: RVO:68081731
Klíčová slova: ERP * P300 * MMN * STN * subthalamic nucleus * internal globus pallidus * thalamus * EEG * DBS
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy

The aim was to compare evoked potentials (EP) from the P300 paradigm against mismatch negativity (MMN) paradigm, both recorded in the subthalamic nucleus (STN), internal globus pallidus (GPi) and thalamus (Th) and thus electrophysiologically isolate conscious cognition component in these structures. We included 8 patients in Deep brain stimulation program and recorded EP (patients with Parkinson´s disease, Generalized dystonia, Essential tremor, Epilepsy). The two four-contacts intracerebral electrodes were implanted into the left and right STN, GPi or Th bilaterally. We computed local potentials on the left and right electrode and we studied the latency of cognitive response (from 200 to 400 ms). The difference between evoked potentials of MMN and P300 protocols in 200-400 ms latency suggests that STN, GPi and They are involved in conscious cognitive processes at the time of stimuli application.
Trvalý link: http://hdl.handle.net/11104/0253230