Structural Alterations of the Language Connectome in Children with Specific Language Impairment

0451407 - ÚI 2016 RIV US eng J - Článek v odborném periodiku
Vydrová, R. - Komárek, V. - Šanda, J. - Štěrbová, K. - Jahodová, A. - Maulisová, A. - Žáčková, J. - Reissigová, Jindra - Kršek, P. - Kyncl, M.
Structural Alterations of the Language Connectome in Children with Specific Language Impairment.
Brain and Language. Roč. 151, December (2015), s. 35-41. ISSN 0093-934X. E-ISSN 1090-2155
Institucionální podpora: RVO:67985807
Klíčová slova: Specific language disorder * DTI * Arcuate fascicle * IFOF * Ventral stream
Kód oboru RIV: BB - Aplikovaná statistika, operační výzkum
Impakt faktor: 3.038, rok: 2015

We evaluated brain white matter pathways associated with language processing in 37 children with specific language impairment aged 6–12 years and 34 controls, matched for age, sex and handedness. Arcuate fascicle (AF), inferior fronto-occipital fascicle (IFOF), inferior longitudinal fascicle (ILF) and uncinate fascicle (UF) were identified using magnetic resonance diffusion tensor imaging (DTI). Diffusivity parameters and volume of the tracts were compared between the SLI and control group. Children with SLI showed decreased fractional anisotropy in all investigated tracts, increased mean diffusivity and radial diffusivity component in arcuate fascicle bilaterally, left IFOF and left ILF. Further, bilaterally increased volume of the ILF in children with SLI was found. We confirmed previous findings indicating deficient connectivity of the arcuate fascicle and as a novel finding, demonstrate abnormal development of the ventral language stream in patients with SLI.
Trvalý link: http://hdl.handle.net/11104/0252575