Reduced gene expression levels after chronic exposure to high concentrations of air pollutants

0451370 - ÚEM 2016 RIV NL eng J - Článek v odborném periodiku
Rössner ml., Pavel - Tulupová, Elena - Rössnerová, Andrea - Líbalová, Helena - Hoňková, Kateřina - Gmuender, H. - Pastorková, Anna - Švecová, Vlasta - Topinka, Jan - Šrám, Radim
Reduced gene expression levels after chronic exposure to high concentrations of air pollutants.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. Roč. 780, oct (2015), s. 60-70. ISSN 0027-5107
Grant CEP: GA MŽP(CZ) SP/1B3/8/08; GA MŠMT(CZ) LO1508; GA ČR GA13-13458S; GA MŠMT 2B08005
Institucionální podpora: RVO:68378041
Klíčová slova: chronic exposure * air pollution * gene expression profiles * human health * particulate matter * polycyclic aromatic hydrocarbons
Kód oboru RIV: DN - Vliv životního prostředí na zdraví
Impakt faktor: 2.581, rok: 2015

We analyzed the ability of particulate matter (PM) and chemicals adsorbed onto it to induce diverse gene expression profiles in subjects living in two regions of the Czech Republic differing in levels and sources of the air pollution. Gene expression profiles differed by locations and seasons. Despite lower concentrations of air pollutants, a higher number of differentially expressed genes and affected KEGG pathways was found in subjects from less polluted region. This observation suggests that chronic exposure to air pollution may result in reduced gene expression response with possible negative health consequences.
Trvalý link: http://hdl.handle.net/11104/0252842