Ixodes ricinus Salivary Serpin IRS-2 Affects Th17 Differentiation via Inhibition of the Interleukin-6/STAT-3 Signaling Pathway

0451279 - BC 2016 RIV US eng J - Článek v odborném periodiku
Páleníková, Jana - Lieskovská, Jaroslava - Langhansová, Helena - Kotsyfakis, Michalis - Chmelař, J. - Kopecký, Jan
Ixodes ricinus Salivary Serpin IRS-2 Affects Th17 Differentiation via Inhibition of the Interleukin-6/STAT-3 Signaling Pathway.
Infection and Immunity. Roč. 83, č. 5 (2015), s. 1949-1956. ISSN 0019-9567. E-ISSN 1098-5522
Grant CEP: GA ČR GAP302/12/2208
Institucionální podpora: RVO:60077344
Klíčová slova: T-cells * Borrelia burgdorferi * transcription factor
Kód oboru RIV: EC - Imunologie
Impakt faktor: 3.603, rok: 2015

Th17 cells constitute a subset of CD4(+) T lymphocytes that play a crucial role in protection against extracellular bacteria and fungi. They are also associated with tissue injury in autoimmune and inflammatory diseases. Here, we report that serpin from the tick Ixodes ricinus, IRS-2, inhibits Th17 differentiation by impairment of the interleukin-6 (IL-6)/STAT-3 signaling pathway. Following activation, mature dendritic cells produce an array of cytokines, including the pleiotropic cytokine IL-6, which triggers the IL-6 signaling pathway. The major transcription factor activated by IL-6 is STAT-3. We show that IRS-2 selectively inhibits production of IL-6 in dendritic cells stimulated with Borrelia spirochetes, which leads to attenuated STAT-3 phosphorylation and finally to impaired Th17 differentiation. The results presented extend the knowledge about the effect of tick salivary serpins on innate immunity cells and their function in driving adaptive immune responses.
Trvalý link: http://hdl.handle.net/11104/0252487