Analysis and characterization of peptide drugs by capillary electromigration methods

0450595 - ÚOCHB 2016 SK eng C - Konferenční příspěvek (zahraniční konf.)
Kašička, Václav - Šolínová, Veronika - Sázelová, Petra - Tůmová, Tereza - Štěpánová, Sille - Koval, Dušan
Analysis and characterization of peptide drugs by capillary electromigration methods.
20th International Conference Analytical Methods and Human Health. Conference Proceedings. Bratislava: Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University in Bratislava, 2015 - (Bodor, R.; Hutta, M.; Masár, M.; Vojs Staňová, A.), s. 27-31. ISBN 978-80-971179-5-5.
[International Conference Analytical Methods and Human Health /20./. Patince (SK), 15.06.2015-18.06.2015]
Grant CEP: GA ČR(CZ) GA13-17224S
Institucionální podpora: RVO:61388963
Klíčová slova: peptides * drugs * capillary electrophoresis
Kód oboru RIV: CB - Analytická chemie, separace

High-performance capillary electromigration methods (HPCE), zone electrophoresis (CZE), affinity electrophoresis (ACE), isotachophoresis (CITP), and micellar electrokinetic chromatography (CMEKC), will be presented as powerful techniques for high-sensitive analysis, high-efficient separation and physicochemical characterization of peptide and peptidomimetic drugs. Applications of HPCE to the analysis, purification and characterization of peptide pharmaceuticals already in the use, e.g. Lecirelin and Carbetocin, as well as of potential new peptide drugs, such as e.g. antimicrobial peptides, gonadotropin releasing hormones (GnRHs) and their analogues and fragments, will be demonstrated.
Trvalý link: http://hdl.handle.net/11104/0251870