Mitochondrial dysfunction and disturbed coherence: Gate to cancer

0449548 - ÚFE 2016 RIV CH eng J - Článek v odborném periodiku
Pokorný, Jiří - Pokorný, Jan - Foletti, A. - Kobilková, J. - Vrba, J. - Vrba, J. jr.
Mitochondrial dysfunction and disturbed coherence: Gate to cancer.
Pharmaceuticals. Roč. 8, č. 4 (2015), s. 675-695. E-ISSN 1424-8247
Institucionální podpora: RVO:67985882 ; RVO:68378271
Klíčová slova: LDH virus * Mitochondrial dysfunction * Cancer biophysics
Kód oboru RIV: JA - Elektronika a optoelektronika, elektrotechnika; BM - Fyzika pevných látek a magnetismus (FZU-D)

Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules’ ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy
Trvalý link: http://hdl.handle.net/11104/0251076