Cell adhesion and growth enabled by biomimetic oligopeptide modification of a polydopamine-poly(ethylene oxide) protein repulsive surface

0449230 - FGÚ 2016 RIV GB eng J - Článek v odborném periodiku
Musílková, Jana - Kotelnikov, Ilya - Novotná, Katarína - Pop-Georgievski, Ognen - Rypáček, František - Bačáková, Lucie - Proks, Vladimír
Cell adhesion and growth enabled by biomimetic oligopeptide modification of a polydopamine-poly(ethylene oxide) protein repulsive surface.
Journal of Materials Science-Materials in Medicine. Roč. 26, č. 11 (2015), s. 253. ISSN 0957-4530. E-ISSN 1573-4838
Grant CEP: GA ČR(CZ) GAP108/11/1857; GA ČR(CZ) GAP108/12/1168; GA MŠMT(CZ) EE2.3.30.0029; GA MŠMT(CZ) ED1.1.00/02.0109
Institucionální podpora: RVO:67985823 ; RVO:61389013
Klíčová slova: protein repulsive surface * cell adhesion * RGD * endothelial cells
Kód oboru RIV: EI - Biotechnologie a bionika; CD - Makromolekulární chemie (UMCH-V)
Impakt faktor: 2.272, rok: 2015

In this study, protein–repulsive polydopamine-poly(ethylene oxide) (PDA-PEO) surfaces were functionalized with an RGD-containing peptide (RGD), with a collagen-derived peptide binding fibronectin (Col), or by a combination of these peptides (RGD + Col, ratio 1:1) in concentrations of 90 fmol/cm2 and 700 fmol/cm2 for each peptide type. A combination of RGD + Col seems to be the most promising for surface modification of biomaterials, e.g. vascular prostheses
Trvalý link: http://hdl.handle.net/11104/0250821