Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds

0447312 - ÚEB 2016 RIV US eng J - Článek v odborném periodiku
Rengasamy, K.R.R. - Amoo, S.O. - Aremu, A.O. - Stirk, W.A. - Grúz, Jiří - Šubrtová, Michaela - Doležal, Karel - van Staden, J.
Phenolic profiles, antioxidant capacity, and acetylcholinesterase inhibitory activity of eight South African seaweeds.
Journal of Applied Phycology. Roč. 27, č. 4 (2015), s. 1599-1605. ISSN 0921-8971. E-ISSN 1573-5176
Grant CEP: GA MŠMT(CZ) LO1204
Institucionální podpora: RVO:61389030
Klíčová slova: Alzheimer's disease * AChE inhibitors * Phenolics
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 2.372, rok: 2015

In the search for new, safe, and natural sources as antioxidant and acetylcholinesterase (AChE) inhibitors, eight seaweeds were collected from the intertidal region in KwaZulu-Natal, South Africa and screened. Their total phenolic, flavonoid, and condensed tannin contents were determined, and the specific phenolic acids were identified. The highest total phenolics, flavonoids, and condensed tannin were recorded in Rhodomelopsis africana (7.89 mg gallic acid equivalents g(-1)), Halimeda cuneata (3.64 mg catechin equivalents g(-1)), and Codium duthieae (0.60 mg cyanide chloride equivalents g(-1)), respectively. Based on UHPLC-MS/MS, different concentrations of protocatechuic acid, p-hydroxybenzoic acid, and m-hydroxybenzoic acid were quantified in the seaweeds. The highest radical scavenging ability and oxygen radical absorbance capacity (ORAC) were observed in red Gelidium foliaceum (52.2 %) and green C. duthieae (44 mu mol TE g(-1)), respectively. In terms of AChE inhibition, the green H. cuneata exhibited greatest bioactivity (IC50 = 70 mu g mL(-1)). Overall, the findings suggest that these seaweeds could be potential candidates as new sources of natural antioxidant and AChE inhibitors.
Trvalý link: http://hdl.handle.net/11104/0249166