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Direct C–H Azidation of Calix[4]arene as a Novel Method to Access Meta Substituted Derivatives
- 1.0446682 - ÚCHP 2016 RIV GB eng J - Článek v odborném periodiku
Stejskal, F. - Eigner, V. - Dvořáková, H. - Cuřínová, Petra - Lhoták, P.
Direct C–H Azidation of Calix[4]arene as a Novel Method to Access Meta Substituted Derivatives.
Tetrahedron Letters. Roč. 56, č. 39 (2015), s. 5357-5361. ISSN 0040-4039. E-ISSN 1873-3581
Institucionální podpora: RVO:67985858
Klíčová slova: calixarene * azidation * regionselectivity
Kód oboru RIV: CC - Organická chemie
Impakt faktor: 2.347, rok: 2015
A novel method for the regioselective meta substitution of calix[4]arenes based on the direct C–H azidation of an amino-substituted calixarene immobilized in the cone conformation is described. Reaction with trimethylsilyl azide and tert-butyl hydroperoxide in the presence of CuBr as a catalyst, provided, depending on the stoichiometry, mono- or bis-azide-substituted derivatives in good yields under mild reaction conditions. meta-Azido calixarenes represent potentially valuable synthetic intermediates for the preparation of calixarenes possessing unusual substitution patterns as demonstrated by a click reaction with p-nitrophenyl acetylene.
Trvalý link: http://hdl.handle.net/11104/0250260
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