Raman Microspectroscopy of Exhaled Breath Condensate and Urine in Workers Exposed to Fine and Nano TiO2 Particles: a Cross-sectional Study

0446180 - ÚCHP 2016 RIV GB eng J - Článek v odborném periodiku
Pelclová, D. - Barošová, H. - Kukutschová, J. - Ždímal, Vladimír - Navrátil, Tomáš - Felclová, Z. - Vlčková, Š. - Schwarz, Jaroslav - Zíková, Naděžda - Kačer, P. - Komarc, M. - Běláček, J. - Zakharov, S.
Raman Microspectroscopy of Exhaled Breath Condensate and Urine in Workers Exposed to Fine and Nano TiO2 Particles: a Cross-sectional Study.
Journal of Breath Research. Roč. 9, č. 3 (2015), s. 036008. ISSN 1752-7155. E-ISSN 1752-7163
Grant CEP: GA ČR(CZ) GBP503/12/G147
Institucionální podpora: RVO:67985858 ; RVO:61388955
Klíčová slova: nanoparticles * TiO2 * titanium
Kód oboru RIV: DN - Vliv životního prostředí na zdraví; CG - Elektrochemie (UFCH-W)
Impakt faktor: 4.177, rok: 2015

The health effects of engineered nanoparticles in humans are not well-understood; however experimental data support the theory of oxidative stress promoting fibrogenesis and carcinogenicity. The aim of this study was to detect TiO2 particles in exhaled breath condensate (EBC) and urine samples to ascertain their presence and potential persistence and excretion in urine. EBC and urine samples were collected from 20 workers exposed to TiO2 aerosol; among them, 16 had a higher risk level of exposure (production workers) and four had medium risk level (research workers); in addition to 20 controls. Titanium levels in EBC and urine were analysed using the inductively coupled plasma mass spectrometry (ICP-MS) method. A Raman microspectroscopic analysis was performed in EBC and urine to identify the phase composition of TiO2 particles observed. Aerosol exposure in the workplaces was measured using SMPS and APS spectrometers and P-TRAK and DustTRAK DRX monitors.
Trvalý link: http://hdl.handle.net/11104/0248241