Involvement of PKC epsilon in Cardioprotection Induced by Adaptation to Chronic Continuous Hypoxia

0444821 - FGÚ 2016 RIV CZ eng J - Článek v odborném periodiku
Holzerová, K. - Hlaváčková, Markéta - Žurmanová, J. - Borchert, Gudrun H. - Neckář, Jan - Kolář, František - Novák, F. - Nováková, O.
Involvement of PKC epsilon in Cardioprotection Induced by Adaptation to Chronic Continuous Hypoxia.
Physiological Research. Roč. 64, č. 2 (2015), s. 191-201. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA ČR(CZ) GAP303/12/1162; GA ČR(CZ) GA13-10267S
Institucionální podpora: RVO:67985823
Klíčová slova: chronic hypoxia * cardioprotection * ventricular myocytes * protein kinase C * PKC epsilon inhibitory peptide KP-1633
Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
Impakt faktor: 1.643, rok: 2015

The aim of this study was to analyse the expression of PKC epsilon after the adaptation to chronic continuous hypoxia (CNH) and to clarify its role in increased cardiac ischemic tolerance with the use of PKC epsilon inhibitory peptide KP-1633. Adaptation to CNH increased myocardial PKC epsilon at protein and mRNA levels. The application of KP-1633 blunted the hypoxia-induced salutary effects on cell viability and LDH release, while control peptide KP-1723 had no effect. This study indicates that PKC epsilon is involved in the cardioprotective mechanism induced by CNH
Trvalý link: http://hdl.handle.net/11104/0247289